Examining the Sensory System
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Cerebral vascular malformations can be classified by histopathology into 4 major types: Arterio-venous malformations (AVMs) Venous angiomas (developmental venous anomalies) Capillary telangiectasias and Cavernous malformations Arterio-venous malformations (AVMs) are congenital vascular lesions due to dysregulated angiogenesis. They are most often solitary but rarely could be multiple, in which case an underlying syndrome (e.g. hereditary haemorrhagic telangiectasia,…
Ischaemic stroke with haemorrhagic transformation, also known as haemorrhagic infarct, occurs in approximately one-third of cases of ischaemic stroke. Haemorrhagic infarct occurs more commonly in the elderly, those with larger infarcts as well as those having received thrombolytic therapy. The mechanism of haemorrhagic infarct has been postulated to be due to the breakdown of the basal…
The MRI images shown here (Figures 1 to 5) are from a patient with cerebral amyloid angiopathy (CAA). CAA is caused by the accumulation of aggregated amyloid-β (Aβ) plaques in the walls of small to medium-sized arteries and penetrating arterioles. Such aggregates are due to an imbalance between Aβ production and clearance. Whilst Aβ40 (40 meaning…
A. Clinical manifestations The clinical manifestations of encephalitis may be similar to those of meningitis. However, altered level of consciousness is a predominant sign. It can range from mild lethargy to deep coma. Moreover, focal or generalized seizures occur in many patients with encephalitis, especially in severe disease. Virtually every possible type of focal neurological…
A. Clinical manifestations The clinical course of brain abscess ranges from indolent to fulminant. Most clinical manifestations are not due to the systemic signs of infection, but rather to the size and site of the abscess. Headache is the most common presenting symptom. Other symptoms and signs include changes in mental status, focal neurological deficits,…
A. Clinical manifestations The clinical manifestations of suppurative intracranial thrombophlebitis depend on the sinus involved, the involvement of anatomical structures within the sinus, and coexisting central nervous system infection. The onset of symptoms may be abrupt or gradual depending on the extent and location of infection. Cavernous sinus: fever (>90%), periorbital oedema (73%), change in…